Spectroscopy Solutions has developed an on-demand version of its 'Applications and New Developments in ICP-MS and Related Techniques eSeminar'. This online educational event will provide those using these techniques updates and guidance on the latest methods, protocols, processes and developments with key experts providing practical insights into their respective fields.
In this presentation Aubrey Galusha and Patrick Parsons from the Laboratory of Inorganic and Nuclear Chemistry, New York State Department of Health, USA will provide some useful strategies for the determination of rare earth elements in biological samples by inorganic mass spectrometry.
Summary
The rare earth elements (REEs) have increased in use over the last several decades with uncertain environmental and public health consequences and, as a result, interest in monitoring REEs in biological samples is escalating. Significant analytical challenges when measuring the REEs in biological tissues include selectivity, sensitivity, accuracy, and the paucity of appropriate matrix-matched reference materials available for method validation. Use of collision/reaction gases, high resolution ICP-MS, extractions, and sample desolvation/electrothermal vaporization are strategies that have been previously employed to overcome sensitivity and selectivity. While certified reference materials are the gold standard for method validation, comparability with other laboratories may also be appropriate.
Method
One approach for the selective determination of REEs in biological specimens leverages ICP-MS/MS – a relatively new technology that enhances the ability to measure REEs as an oxide (or other molecular ion) with greater control over the reaction products compared to single quadrupole instruments. The oxygen mass shift was evaluated for 31 REE isotopes in bone, following internal standard evaluation and gas flow-rate optimization. Accuracy was assessed with reference materials where possible, and comparability with other measured values was also evaluated.
By viewing this presentation you will be able to:
- Describe the analytical difficulties of analysing biological samples for REEs
- Explain some strategies for overcoming those challenges
