The past year marked a milestone for the Separation Science editorial team as we expanded our coverage, tackled emerging challenges, and explored the latest innovations shaping analytical science. From in-depth features in our digital issues to expert-led interviews and webinars, we provided content that kept scientists informed and inspired.
Highlights included thought-provoking discussions on sustainability, artificial intelligence, and advanced instrumentation, as well as practical advice for troubleshooting and improving workflows. Through articles, videos, event coverage, and more, we strived to deliver actionable insights across chromatography, mass spectrometry, and spectroscopy.
Here’s a look back at some of the most impactful content from 2024:
Machine Learning in Mass Spectrometry Data Analysis
Aimee Cichocki
The integration of machine learning into mass spectrometry workflows continued to progress in 2024. This discussion with expert Will Fondrie explains how these techniques automate data interpretation, reducing errors and opening doors to more comprehensive insights from large datasets.
Understanding MRM Fundamentals: Dwell Time, Cycle Time, and Duty Cycle
Adam Dickie
This in-depth piece demystifies key concepts in multiple reaction monitoring (MRM). By breaking down dwell time, cycle time, and duty cycle, it provided critical insights for analysts working to optimize their LC-MS/MS methods.
New Frontiers: Exploring the Potential of Advanced Ion Mobility Mass Spectrometry
Daniel DeBord
Advanced ion mobility mass spectrometry continues to push the boundaries of what’s possible in separation science. This article explores its ability to achieve unprecedented levels of resolution, providing critical insights for researchers working on complex samples.
AAVs Explained: Structure, Safety, and Analytical Chemistry
Adam Dickie
As gene therapy continues to advance, understanding the structure and safety of adeno-associated viruses (AAVs) has become critical. This article breaks down the analytical techniques used to characterize AAVs, offering valuable insights for researchers in this rapidly growing field.
Implementing AI to Streamline Chromatographic Peak Picking
Holden Galusha
As AI continues to make waves in analytical labs, this article showcases its application in automating chromatographic peak picking. By reducing manual errors and speeding up workflows, AI is enabling scientists to focus on high-value tasks such as method development and interpretation.
When GC Retention Times Shift: Practical Advice for Operators
Adam Dickie
Gas chromatographers often encounter retention time shifts, which can disrupt analyses and lead to inconsistent results. This article provides practical tips to diagnose and correct these shifts, from maintaining consistent oven temperatures to troubleshooting column performance issues.
ASMS 2024: Pioneering the Future of Mass Spectrometry
Aimee Cichocki
The ASMS 2024 annual conference brought together global experts to discuss the latest advances in mass spectrometry. From breakthroughs in ion mobility to novel applications in biomarker discovery, the event highlighted the growing versatility of mass spectrometry methods. Our coverage captured the most significant takeaways and trends that will shape mass spectrometry in the years to come.
Considerations for Selecting and Maintaining Column Phases for Optimizing Liquid Chromatography
Philip Koerner
Column phase selection can make or break liquid chromatography methods. This guide offers expert advice on choosing the right column phase and maintaining its performance to ensure robust, reproducible results over time.
From Lab to Field: The Impact of Portable FTIR in Forensics
Aimee Cichocki
Portable FTIR technology has revolutionized forensic science, enabling investigators to perform on-site analyses with accuracy that previously required laboratory conditions. This interview with 908 Device’s Christopher D. Brown details the impact of portable FTIR on criminal investigations, including faster evidence processing and more reliable results.
Harnessing Eco-Friendly Solvents for Greener Liquid Chromatography
Adam Dickie
Sustainability remained a key theme across the industry in 2024. This piece outlines practical strategies for adopting eco-friendly solvents in liquid chromatography without compromising performance.
Overcoming the Challenges of Nitrosamine Analysis Using LC-MS/MS
Jack Steed
As regulatory scrutiny of nitrosamines intensifies, this article addresses practical solutions for accurate and reliable analysis.
Mass Spectrometry Takes Flight to Unlock Europa’s Chemistry
Adam Dickie
One of the year’s most captivating stories highlights the role of mass spectrometry in NASA’s mission to Europa. This feature delves into how the technology will help uncover the moon’s chemical composition, potentially revealing signs of life beneath its icy surface.
Unveiling the Power of Mass Photometry in Biomolecular Analysis
Aimee Cichocki
Mass photometry emerged as a key tool for biomolecular analysis in 2024. This with Refeyn’s Stephen Maughan highlights its ability to provide precise mass measurements with minimal sample requirements, making it an invaluable resource for researchers in structural biology.
Developments in MALDI Imaging Technology Further Advance Clinical Research
Kate Stumo
MALDI imaging continues to shine as a transformative tool in clinical research. This article explored its applications in tissue analysis, biomarker discovery, and disease diagnostics, emphasizing how recent advancements are expanding its utility.
Petroleum Analysis: Ensuring Accuracy and Consistency in a Changing Industry
Aimee Cichocki
The petroleum industry faced new challenges in 2024, from tighter regulations to evolving energy markets. This interview with expert Larry Tucker detailed the analytical techniques essential for ensuring product accuracy and consistency in a rapidly changing landscape.
Looking Ahead
As we enter 2025, we’re proud of the diverse and impactful content we delivered to the analytical community. Thank you for being part of the journey, and we look forward to bringing you even more insights and innovations in the coming year!
