This technical article discusses the possible effect caused from interactions between changes from different variables.
In this instalment of the series we look at allowed adjustments to HPLC methods. In the previous instalments (Part 1, Part 2, Part 3, Part 4, Part 5), we’ve looked at each of the specific variables listed in Table 1.
Interactions
The allowed adjustment of the variables listed in Table 1 are each listed separately, but a change in some of these can have a cascading influence on other variables. Let’s consider a change in packing particle size as an example.
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