Methods & Applications eBook

Gold Standards in Air Monitoring: Solvent, Helium, and Cryogen-Free Technologies for Regulatory Compliance

Gain insights into how cutting-edge air monitoring technologies are setting new standards for regulatory compliance and VOC detection in complex air samples.

There is an increasing demand for accurate and efficient air quality monitoring, driven by growing public awareness and stricter regulations. Laboratories and environmental agencies face the challenge of detecting hazardous air pollutants and volatile organic compounds (VOCs) with both precision and efficiency. Achieving compliance with monitoring methodologies—such as US EPA Methods TO-15A and TO-17 and Chinese EPA Method HJ 759—requires advanced technologies that provide highly sensitive trace VOC detection while remaining user-friendly, flexible, and easy to operate.

This eBook presents gold-standard technologies for air monitoring, including tube, canister, or online sampling, with a focus on the latest thermal desorption (TD) and automated pre-concentration techniques for GC-MS. These methods not only ensure compliance with global air monitoring regulations but also offer exceptional precision and sensitivity. Moreover, they eliminate the need for solvents and cryogenic cooling, providing cost-saving benefits and improved performance in environments with high humidity and complex pollutant profiles.

The eBook offers detailed insights into how cutting-edge air monitoring technologies are setting new standards for regulatory compliance and VOC detection in complex air samples.

Application examples include:

Advances in Ultra-Trace Air Toxics Analysis
This application note explores automated GC-MS analysis of air toxics under US EPA Method TO-15A, demonstrating superior detection limits and enhanced sample throughput for 75 target compounds.


Cryogen-Free Monitoring of Ozone Precursors and Air Toxics
This application note describes a method for detecting over 100 hazardous airborne volatile compounds, in line with Chinese EPA Method HJ 759, without the use of liquid nitrogen or cryogenic cooling.


Measurement of PFAS in Indoor Air
This application note examines the detection and quantification of per- and polyfluoroalkyl substances (PFAS) in indoor environments, using cryogen-free, high-throughput TD-GC-MS/MS systems.

Also featured is the case study below:

Unattended PAMS Monitoring of Ultra-Volatiles
This case study showcases the New York State Department of Environmental Conservation’s success in achieving 100% data coverage using cryogen- and cylinder-free TD-GC technology to monitor ozone precursors and ultra-volatile compounds in compliance with PAMS guidelines.

Learning Objectives

  • How to meet global standard methods and ensure regulatory compliance for air toxics monitoring, including US EPA Methods TO-17 and 325B, Chinese EPA Method HJ 759, and the EU Air Quality Directive 2008/50/EC.
  • See the innovations in monitoring technology allowing continuous, unattended monitoring of VOCs with effective water management, cryogen-free preconcentration, and use of sustainable carrier gasses such as hydrogen – all while maintaining high analytical performance, reducing environmental impact, and being method compliant.
  • How contract labs employ TD–GC–MS technologies to automate and improve their air monitoring workflow, remove moisture, and increase throughput for a wide range of analytes.

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