Would a modified QuEChERS approach help you to analyse complex biological matrices? If so, this presentation will show you how to apply a QuEChERS method for sample clean-up of one of toxicology’s more difficult specimens to handle, post-mortem liver, for the analysis of several common prescription and illicit drugs.
Introduction
Traditional sample extraction methods tend to focus on a small number of compounds or a single drug class to achieve the most optimal results. Unfortunately, with enhanced specificity comes increases in overall sample prep time and cost. The high demands placed on toxicology laboratories to produce accurate results in a concise period of time has since fuelled a mass transition towards universal sample preparation techniques. These broad approaches are fast and efficient; however, since many of these methods are not as selective, analysts may be compromising on analyte recovery and overall sample cleanliness. One possible solution toxicology laboratories are beginning to explore is the QuEChERS (Quick, Easy, Cheap, Effective, Rugged and Safe) approach. Crossing over from the food safety industry, this technique has proven to be a reliable alternative when extracting multiple drug classes from challenging biological matrices. Today’s presentation will discuss a modified QuEChERS method for sample clean-up of one of toxicology’s more difficult specimens to handle, post-mortem liver, for the analysis of several common prescription and illicit drugs.
Learn more
To find out more Separation Science is hosting a presentation by Tina Fanning of UCT who will be speaking about the development of a modified QuEChERS approach for the extraction of common prescription and illicit drugs from liver prior to LC/MS-MS analysis as part of its upcoming 'Advances in Forensics & Toxicology' eSeminar this month. Simply register for the eSeminar to access the presentation.
About the presenter
Tina Fanning is responsible for both application development and customer technical support at UCT. This position allows her to travel across the world and meet with scientists to discuss sample preparation techniques and conduct educational workshops on analytical methods. With a background in forensics, Tina has helped to introduce the concept of QuEChERS to the toxicology community as they begin to take a heightened interest in this sample preparation technique for biological matrices. Along with other members of the research and development team at UCT, she has been at the forefront of method development for emerging synthetic drugs of abuse. Tina utilizes her previous experience of working in a large reference laboratory to help streamline the sample preparation process for clients in a variety of laboratory settings. She received her M.S. in Forensic Science and Law from Duquesne University
For a full list of presentations featured in the 'Advances in Forensics & Toxicology' eSeminar click the button below and discover the latest information as delivered by our expert panel of speakers.
