In the ever-evolving field of endocrine testing by LC-MS/MS, the choice of chromatographic column can significantly impact the accuracy and reliability of results. Separation Science recently had the pleasure of interviewing Dr. Stephanie Marin, the Global Clinical Market Development Manager at Phenomenex, to delve into this critical aspect of assay development.
With over a decade of experience in clinical assay validation and a deep expertise in liquid chromatography and mass spectrometry, Dr. Marin offers invaluable insights into the nuances of column selection for endocrine testing. In this conversation, she addresses key considerations, from the importance of looking beyond traditional C18 columns to the latest advancements in column technology that are shaping the future of endocrine analysis.
In this interview, Dr. Marin responds to the following questions:
- Could you provide a brief overview of the various column chemistries available for endocrine testing by LC-MS/MS?
- Why is it important to look beyond just a C18 column for endocrine testing?
- What are the main factors that researchers should consider when selecting a column for endocrine testing?
- Are there any particular column chemistries that you would recommend for specific types of endocrine compounds?
- Have there been any recent advancements in column technology that are particularly beneficial for endocrine testing?
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