Application Note

Size-Exclusion Chromatography of Adeno-Associated Viruses with 3 µm Thermo Scientific SurePac Bio 550 SEC MDi Column

Learn how baseline resolution of AAV monomer and aggregate peaks can be achieved in less than 4 minutes.

This application demonstrates high-resolution separation of monomeric AAV and aggregates by size-exclusion liquid chromatography within 4 minutes. It introduces new columns powered by MDi technology, which integrates advanced monodisperse silica particle platforms with biocompatible hardware.

Download this application note to discover the key benefits:

  • High-resolution separation of monomeric AAV and aggregates by size-exclusion liquid chromatography within 4 minutes
  • Utilizing UV and fluorescence detection for easy and conclusive confirmation of peak identities
  • Resolution of aggregate and monomer peaks preserved even for injection of large volumes
  • Consistent lot-to-lot and column-to-column performance

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